Bijuve – common side effects

Bijuve is a medication that combines estradiol and progesterone, used in hormone replacement therapy (HRT) for postmenopausal women to relieve symptoms of menopause and in gender-affirming care. It’s important to understand the potential unwanted/adverse/side effects that could be relevant in the context of gender-affirming care. Here are some potential side effects:

Breast tenderness/enlargementBoth estradiol and progesterone can cause breast tenderness, soreness, and enlargement due to their effects on breast tissue development.
Mood changesHormone therapy, including estradiol and progesterone, may lead to mood changes, including mood swings, irritability, or changes in emotional well-being.
FatigueFatigue or feelings of lethargy may occur as a side effect of hormone therapy.
HeadachesHeadaches are a common side effect of hormone therapy. These headaches may range from mild to moderate in severity.
NauseaNausea or gastrointestinal discomfort may occur as a side effect of hormone therapy, though this is usually mild and transient.
Fluid retentionHormone therapy may lead to fluid retention, causing swelling or bloating in the hands, feet, or other parts of the body.
Weight changesSome individuals may experience changes in body weight or distribution as a side effect of hormone therapy.
Skin changesHormone therapy may cause changes in skin texture, including increased softness or oiliness, as well as changes in pigmentation.
Menstrual-like bleedingSome individuals may experience breakthrough bleeding or spotting while using hormone therapy, particularly during the initial stages of treatment.
Rare allergic reactionsAlthough rare, some individuals may experience allergic reactions to hormone therapy, including rash, itching, swelling, or difficulty breathing. Immediate medical attention is necessary if any signs of an allergic reaction occur.

Updated on February 6, 2024

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