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Crinonone 8% progesterone vaginal gel – common side effects

Crinone 8% is a vaginal gel containing micronised progesterone, a natural form of the hormone progesterone. While it is more commonly used in fertility treatments, it has also been used off-label in gender-affirming care for transgender women (assigned male at birth) or individuals with androgen-dependent conditions. Progesterone therapy is often prescribed in combination with estrogen therapy to help promote breast development and mimic the hormonal profile of cisgender women. Here are some potential unwanted/adverse/side effects of Crinone 8% in the context of gender-affirming care:

Side EffectDescription
Vaginal irritationSome individuals may experience vaginal irritation, itching, or discharge as a side effect of using Crinone 8%.
Mood changesProgesterone therapy, including Crinone use, may lead to mood changes, including mood swings, irritability, or changes in emotional well-being.
FatigueFatigue or feelings of lethargy may occur as a side effect of Crinone therapy.
HeadachesHeadaches are a common side effect of progesterone therapy, including Crinone use. These headaches may range from mild to moderate in severity.
Breast tenderness/enlargementProgesterone therapy can cause breast tenderness, soreness, and enlargement due to its effects on breast tissue development.
Fluid retentionProgesterone therapy may lead to fluid retention, causing swelling or bloating in the hands, feet, or other parts of the body.
Weight changesSome individuals may experience changes in body weight or distribution as a side effect of progesterone therapy.
Skin changesProgesterone therapy may cause changes in skin texture, including increased softness or oiliness, as well as changes in pigmentation.
Menstrual-like bleedingSome individuals may experience breakthrough bleeding or spotting while using Crinone, particularly during the initial stages of treatment.
Rare allergic reactionsAlthough rare, some individuals may experience allergic reactions to Crinone, including rash, itching, swelling, or difficulty breathing. Immediate medical attention is necessary if any signs of an allergic reaction occur.


Updated on February 6, 2024

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