Cyclogest – common side effects

Cyclogest is a brand name for progesterone suppositories containing micronised progesterone, a natural form of the hormone progesterone. While it is more commonly used in the context of fertility treatments and hormonal support during pregnancy, it has also been used off-label in gender-affirming care for transgender women (assigned male at birth) or individuals with androgen-dependent conditions. Progesterone therapy is often prescribed in combination with estrogen therapy to help promote breast development and mimic the hormonal profile of cisgender women. Here are some potential unwanted/adverse/side effects of Cyclogest in the context of gender-affirming care:

Side EffectDescription
Gastrointestinal discomfortSome individuals may experience gastrointestinal discomfort, such as bloating, gas, or abdominal pain, as a side effect of using Cyclogest suppositories.
Vaginal discharge or irritationInsertion of suppositories may cause vaginal discharge or irritation in some individuals.
Mood changesProgesterone therapy, including Cyclogest use, may lead to mood changes, including mood swings, irritability, or changes in emotional well-being.
FatigueFatigue or feelings of lethargy may occur as a side effect of Cyclogest therapy.
HeadachesHeadaches are a common side effect of progesterone therapy, including Cyclogest use. These headaches may range from mild to moderate in severity.
Breast tenderness and enlargementProgesterone therapy can cause breast tenderness, soreness, and enlargement due to its effects on breast tissue development.
Fluid retentionProgesterone therapy may lead to fluid retention, causing swelling or bloating in the hands, feet, or other parts of the body.
Weight changesSome individuals may experience changes in body weight or distribution as a side effect of progesterone therapy.
Skin changesProgesterone therapy may cause changes in skin texture, including increased softness or oiliness, as well as changes in pigmentation.
Menstrual-like bleedingSome individuals may experience breakthrough bleeding or spotting while using Cyclogest suppositories, particularly if they have not undergone surgical removal of the gonads.
Rare allergic reactionsAlthough rare, some individuals may experience allergic reactions to Cyclogest, including rash, itching, swelling, or difficulty breathing. Immediate medical attention is necessary.

Updated on February 6, 2024

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