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Epilepsy and Gender-Affirming Care: Considerations and Management


Epilepsy is a neurological disorder characterised by recurrent, unprovoked seizures. Managing epilepsy in the context of gender-affirming care presents unique challenges and considerations. This article explores the intersection of epilepsy management and gender-affirming treatments, highlighting the importance of personalized care.

Understanding Epilepsy

Epilepsy encompasses a range of seizure types and syndromes, each with its own set of triggers, manifestations, and treatment approaches. The condition is typically managed with antiepileptic drugs (AEDs), which can have various interactions with hormones used in gender-affirming therapies.

Gender-Affirming Care and Hormone Therapy

Gender-affirming care often involves hormone replacement therapy (HRT), where transgender individuals receive hormones and hormone blockers to align their physical characteristics with their gender identity.

Safety and Vigilance in Gender-Affirming Care for Individuals with Epilepsy

Transitioning with hormone therapy is quite safe for individuals with epilepsy. However, it’s important to maintain vigilance regarding seizure activity. Always keep a close eye on any changes in your seizure patterns or frequency as you undergo gender-affirming treatment. It’s important to take appropriate measures to manage your epilepsy, adhering strictly to your seizure management plan and medication regimen. Equally essential is open communication with your healthcare providers. Make sure to inform your neurologist or epilepsy specialist about your hormone therapy and any other new medications you start. This allows them to monitor for potential interactions between your antiepileptic drugs and hormone treatments and make any necessary adjustments to ensure both your neurological health and your gender-affirming care are managed optimally and safely.


Epilepsy management in the context of gender-affirming care requires a nuanced and individualised approach. Understanding the interactions between AEDs and hormone therapies is key to providing safe and effective care. With careful monitoring and a collaborative approach between healthcare providers, individuals with epilepsy can successfully navigate gender-affirming treatments while effectively managing their neurological condition.

Further reading
Johnson, E. L., and Kaplan, P. W. (2017). “Caring for Transgender Patients With Epilepsy”. Epilepsia, 58: 1667-1672.”

Updated on January 27, 2024

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