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Estradiol Enanthate injections – common side effects


In the context of gender-affirming care, estradiol enanthate injections are commonly used as a form of estrogen therapy for transgender women or individuals undergoing feminizing hormone therapy. While estradiol enanthate can be effective in promoting feminization and aligning secondary sexual characteristics with gender identity, it’s important to be aware of potential unwanted, adverse, or side effects. Here are some possible effects:

Side EffectDescription
Breast Tenderness and EnlargementEstradiol enanthate injections can lead to breast tenderness, soreness, and enlargement due to the stimulation of breast tissue development.
Mood ChangesSome individuals may experience mood swings, irritability, or changes in emotional wellbeing as a result of estradiol enanthate therapy.
FatigueFatigue or feelings of lethargy may occur as a side effect of estradiol enanthate therapy, particularly during the initial period of adjustment.
HeadachesHeadaches are a common side effect of estrogen therapy, including estradiol enanthate use. These headaches may range from mild to moderate in severity.
NauseaNausea or gastrointestinal discomfort may occur as a side effect of estradiol enanthate therapy, though this is usually mild and transient.
Fluid RetentionEstradiol enanthate therapy can lead to fluid retention, causing swelling or bloating in the hands, feet, or other parts of the body.
Weight ChangesSome individuals may experience changes in body weight or distribution as a side effect of estradiol enanthate therapy.
Skin ChangesEstradiol enanthate therapy may cause changes in skin texture, including increased softness or oiliness, as well as changes in pigmentation.
Decreased LibidoA decrease in libido (sex drive) can occur as a side effect of estradiol enanthate therapy due to changes in hormone levels.
Thromboembolic EventsWhile less common, there is a risk of thromboembolic events (such as blood clots) associated with estradiol enanthate therapy, particularly in individuals with other risk factors for thrombosis.

*Please note that these injections are not available in all countries (eg UK)
**Self-administration should only happen after proper training. You can book your injection training session here:

Updated on February 16, 2024

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