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Keeping Gender-Affirming Medications in the Fridge: A Guide


Gender-affirming medications play a crucial role in the lives of many transgender and non-binary individuals and many people ask whether or not they should keep their injectables in the fridge, however the specific storage requirements depend on the type and brand of medication.

Why Refrigeration Matters

Some medications, particularly certain injectables, might need to be stored in a refrigerator for the following reasons:

  • Stability: Refrigeration can help maintain the medication’s chemical stability, ensuring it remains effective until its expiration date.
  • Prevention of Spoilage: Just like perishable food, some medications can spoil if not stored correctly. Heat can accelerate chemical reactions that may degrade the medicine.
  • Safety: Proper storage reduces the risk of contamination and ensures the medication is safe to use.

Tips for Refrigerating Medications

  • Check Instructions: Always read the storage instructions on the medication label or package insert. If in doubt, consult with a pharmacist.
  • Consistent Temperature: The fridge should be at a consistent temperature, ideally between 2°C and 8°C (35.6°F to 46.4°F). Avoid storing medication in the door, as this area experiences the most temperature fluctuation.
  • Avoid Freezing: Some medications can lose their effectiveness if frozen. Ensure they are stored in a part of the fridge that doesn’t risk freezing.
  • Accessibility and Safety: Keep medications out of reach of children and pets. Use a dedicated box or area in the fridge to avoid confusion with food items.
  • Travel Considerations: If traveling, use a cool bag or portable fridge to keep the medication at the right temperature.

Does my medication need to be kept in the fridge?

Leuprorelin: Typically, leuprorelin depot formulations (like injections that are administered monthly, quarterly, or yearly) do not require refrigeration and can be stored at room temperature, away from heat and direct sunlight. However, this can vary, so it’s crucial to check the specific storage instructions provided with the medication or consult with a pharmacist or healthcare provider.

For instance, some formulations of leuprorelin may need to be stored in a refrigerator until they are mixed. Once mixed, they might not require refrigeration but should be used within a certain timeframe.

Triptorelin: In general, most formulations of Triptorelin do not require refrigeration and can be stored at room temperature, typically between 20°C to 25°C (68°F to 77°F). However, it is essential to avoid extreme temperatures and to keep the medication away from direct light and moisture.

GnRH agonists (Gonadotropin-releasing hormone agonists), often used in various medical treatments including hormone therapy, can have different storage requirements depending on the specific medication and formulation. These medications come in various forms, including injections, and their storage instructions may vary.

For many GnRH agonists, refrigeration is not typically required, and they can be stored at room temperature. However, this can depend on the specific product.

It is crucial to check the storage instructions for the specific GnRH agonist you are using. This information can be found on the medication label, the package insert, or obtained from a pharmacist or healthcare provider.

Sustanon: a form of testosterone used in hormone therapy, typically does not need to be refrigerated. It is usually stored at room temperature, away from moisture, heat, and direct light. The storage conditions for Sustanon and other injectable testosterone products often recommend keeping them in a cool, dry place.

Nebido: a brand of testosterone undecanoate used in testosterone replacement therapy, generally does not require refrigeration. It should be stored at room temperature, away from moisture and heat. The typical storage recommendation for Nebido is to keep it in a cool, dry place, ideally at temperatures below 30°C (86°F).

Testosterone Enanthate: commonly used for testosterone replacement therapy, typically does not require refrigeration. It should be stored at room temperature, away from extreme temperatures, moisture, and direct light. The recommended storage conditions are usually to keep it in a cool, dry place.


It is always important to check the specific storage instructions that come with your medication, as these instructions can vary depending on the manufacturer and the specific formulation. The packaging or the accompanying patient information leaflet should provide clear guidance on how to store the product correctly.

If you’re ever in doubt about how to store any medication, it’s best to ask your pharmacist. They can give you the most accurate and relevant information for your specific medication about how to properly store your medication.

What to Do in Case of Improper Storage

If you suspect your medication has been stored improperly (e.g., left out of the fridge for an extended period), consult your pharmacist before using it. They can advise whether the medication is still safe and effective.


Proper storage of gender-affirming medications is vital for their effectiveness and safety. For those that require refrigeration, it’s important to adhere to the recommended storage conditions.

Updated on January 22, 2024

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