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Patient Information Leaflet: SERMs (Selective Estrogen Receptor Modulators) in Gender-Affirming Care

This leaflet provides information about Selective Estrogen Receptor Modulators (SERMs), for example Raloxifene, and their use in gender-affirming care. It is designed to help you understand the benefits, risks, and important considerations associated with this medication.

What are SERMs?
Selective Estrogen Receptor Modulators (SERMs) are a class of drugs that act on the estrogen receptors in the body. They are unique because they can act as estrogen activators or blockers, depending on the specific tissue they are affecting.

Raloxifene in Gender-Affirming Care:
Raloxifene is a type of SERM that is often used in gender-affirming care, particularly for individuals who are seeking to suppress estrogenic effects without the use of traditional hormone blockers. It is commonly used for its anti-estrogen effects in certain tissues.


  • Used as part of feminising hormone therapy, particularly for transgender women or non-binary individuals who are sensitive to or wish to avoid certain effects of estrogen.
  • SERMs are often used to treat estrogen-related conditions, such as infertility, osteoporosis, and some types of breast cancer.

Benefits of Raloxifene:

  • Helps in reducing estrogenic effects such as breast development.
  • Can provide a more controlled approach to feminising hormone therapy.
  • May have beneficial effects on bone density.

Potential Side Effects:
As with any medication, Raloxifene can cause side effects. These may include:

  • Hot flashes
  • Leg cramps
  • Increased risk of blood clots
  • Possible liver function changes

Dosage and Administration:

  • The dosage of Raloxifene will be determined by your healthcare provider based on your specific needs.
  • It is usually taken orally, once a day.


  • Inform your healthcare provider about any other medications you are taking, as Raloxifene can interact with other drugs.
  • Regular monitoring of blood tests may be necessary to check liver function and blood clotting factors.
  • Not recommended for individuals with a history of blood clots.

Important Considerations:

  • Raloxifene is not a complete substitute for traditional hormone therapy but can be an important part of a broader treatment plan.
  • Continuous communication with your specialist team is crucial for monitoring the effectiveness and any side effects of the treatment.

Raloxifene, as part of gender-affirming care, offers an alternative for those seeking to modify the effects of estrogen on their bodies. It’s important to be fully informed to see if this medication is suitable for you and to monitor your health throughout the treatment.

This leaflet is for informational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your healthcare provider with any questions you may have regarding a medical condition.

More information:


Updated on January 23, 2024

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