Provera – common side effects

Provera, also known as medroxyprogesterone acetate, is a synthetic progestin commonly used in various medical contexts, including hormone replacement therapy and birth control. In the context of gender-affirming care for transgender women (assigned male at birth) or individuals with androgen-dependent conditions, it may be prescribed to help promote breast development and mimic the hormonal profile of cisgender women. However, it’s important to be aware of potential unwanted/adverse/side effects. Here are some of them:

Side EffectDescription
Breast tenderness and enlargementProvera therapy can cause breast tenderness, soreness, and enlargement due to its effects on breast tissue development.
Mood changesSome individuals may experience mood swings, irritability, or changes in emotional well-being while taking Provera therapy.
FatigueFatigue or feelings of lethargy may occur as a side effect of Provera therapy.
HeadachesHeadaches are a common side effect of Provera therapy. These headaches may range from mild to moderate in severity.
NauseaNausea or gastrointestinal discomfort may occur as a side effect of Provera therapy, though this is usually mild and transient.
Fluid retentionProvera therapy may lead to fluid retention, causing swelling or bloating in the hands, feet, or other parts of the body.
Weight changesSome individuals may experience changes in body weight or distribution as a side effect of Provera therapy.
Skin changesProvera therapy may cause changes in skin texture, including increased softness or oiliness, as well as changes in pigmentation.
Menstrual-like bleedingProvera therapy can cause breakthrough bleeding or spotting, particularly during the initial stages of treatment.
Decreased libidoSome individuals may experience a decrease in libido (sex drive) while taking Provera therapy.
Rare allergic reactionsAlthough rare, some individuals may experience allergic reactions to Provera, including rash, itching, swelling, or difficulty breathing. Immediate medical attention is necessary if any signs of an allergic reaction occur.

https://labeling.pfizer.com/showlabeling.aspx?id=606

Updated on February 6, 2024

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