Spironolactone  in Gender-Affirming Care: An overview


Gender-affirming care encompasses various medical interventions aimed at aligning an individual’s physical characteristics with their gender identity. Hormonal transition, a fundamental aspect of this process, often involves medications like spironolactone, which plays a crucial role in suppressing endogenous hormone production and facilitating desired hormonal changes.

Spironolactone and Testosterone Suppression

For transgender women (assigned male at birth), the suppression of testosterone is essential for feminization. Spironolactone, a potassium-sparing diuretic with anti-androgenic properties, acts by blocking the effects of androgens like testosterone at the receptor level and inhibiting testosterone production. By reducing testosterone levels, spironolactone helps diminish masculine secondary sexual characteristics such as body hair growth and muscle mass.

Facilitating Feminization

Spironolactone serves as a cornerstone in the feminization process for transgender women, enabling the development of secondary sexual characteristics consistent with their gender identity. By creating a hormonal environment conducive to feminization, spironolactone enhances gender affirmation and contributes to overall well-being, empowering individuals on their journey towards self-acceptance.

Management of Androgenetic Alopecia

In addition to its role in hormone therapy, spironolactone offers benefits in managing androgenetic alopecia, a common concern among transgender women. Hair loss can be distressing and may hinder the process of gender transition. Spironolactone’s anti-androgenic properties help mitigate hair loss and promote hair regrowth, further supporting the feminization process and boosting self-confidence.

Dosage and Administration

Spironolactone is typically administered orally, with dosages ranging from 25 mg to 200 mg per day, depending on the specific treatment protocol and individual response. Healthcare providers specializing in transgender care will tailor the dosage and frequency of administration to optimize testosterone suppression while minimizing side effects.


Spironolactone stands as a pillar of hormonal transition in gender-affirming care, offering precise and effective suppression of endogenous hormone production to align with an individual’s gender identity. By facilitating the development of secondary sexual characteristics consistent with the desired gender, spironolactone plays a vital role in supporting transgender women on their journey towards self-affirmation, empowerment, and improved quality of life. As part of a comprehensive treatment approach, spironolactone empowers individuals to embrace their authentic selves, fostering resilience, confidence, and overall well-being in their pursuit of gender affirmation.

Updated on February 12, 2024

Was this article helpful?

Related Articles

Request an article
If you would like some knowledge added to our knowledge base, send your suggestions here.
Request Knowledge