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Synarel/Synarela spray  in Gender-Affirming Care: An overview


Gender-affirming care encompasses a range of medical interventions aimed at aligning an individual’s physical characteristics with their gender identity. Hormonal transition, a key aspect of this process, often involves medications like Synarel nasal spray, which plays a crucial role in suppressing endogenous hormone production and facilitating desired hormonal changes.

Synarel Nasal Spray and Hormonal Suppression

Synarel (Nafarelin acetate) is a gonadotropin-releasing hormone (GnRH) agonist, commonly delivered in the form of a nasal spray. Its primary function is to suppress the production of sex hormones, such as testosterone in assigned males at birth and estrogen in assigned females at birth. By desensitizing the pituitary gland, Synarel decreases the secretion of gonadotropins, which in turn suppresses the production of sex hormones from the gonads.

Facilitating Hormonal Transition

Synarel plays a vital role in supporting hormonal transition for transgender individuals by creating a hormonal environment consistent with their gender identity. By suppressing endogenous hormone production, Synarel helps facilitate the development of secondary sexual characteristics congruent with the individual’s desired gender. This includes reducing the effects of testosterone in transgender women and estrogen in transgender men, contributing to gender affirmation and overall well-being.

Dosage and Administration

Synarel nasal spray is typically administered intranasally, with dosages varying based on individual requirements and treatment protocols. Healthcare providers specializing in transgender care will determine the appropriate dosage and frequency of administration to achieve optimal hormonal suppression while minimizing side effects.


Synarel nasal spray serves as a valuable tool in gender-affirming care, offering precise and effective suppression of endogenous hormone production to align with an individual’s gender identity. By facilitating the development of secondary sexual characteristics consistent with the desired gender, Synarel plays a crucial role in supporting transgender individuals on their journey towards self-affirmation, empowerment, and improved quality of life. As part of a comprehensive treatment approach, Synarel empowers individuals to embrace their authentic selves, fostering resilience, confidence, and overall well-being in their pursuit of gender affirmation.

Updated on February 12, 2024

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