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The Psychological Impact of Hormone Therapy Balancing the Positives and Negatives


Hormone therapy, a cornerstone in gender-affirming treatment, can have an impact mental and psychological health. This article explores both the positive and negative effects of hormone therapy on mood and existing mental health conditions.

Positive Effects

  • Alleviation of Gender Dysphoria: Hormones can profoundly reduce feelings of gender dysphoria, leading to improved mental well-being.
  • Enhanced Mood and Self-Esteem: Many individuals experience an uplift in mood and self-esteem as their physical appearance aligns more closely with their gender identity.
  • Alignment: The alignment of one’s psychological self with the correct hormone profile can profoundly resonate with their core identity, fostering a sense of congruence and wellbeing in their overall mental and emotional state.
  • Improvement in Mental Health Issues: Hormonal changes can sometimes lead to an improvement in pre-existing mental health conditions, providing a more stable and positive mental state.

Negative Effects

  • Mood Fluctuations: Hormone therapy can cause mood swings, especially in the initial stages.
  • Impact on Pre-existing Conditions: Existing mental health issues may be exacerbated by hormonal changes.
  • Monitoring and Support: Regular monitoring and surveillance is crucial. Mental health support should be part of the treatment plan.
  • Adjusting to Hormonal Changes: The body and mind may take time to adjust to new hormone levels, and some effects may be temporary.


Hormone therapy can be transformative, and it is important to have an understanding of its complex effects on mental health. Ongoing support and open communication are key to navigating these changes successfully.

Updated on January 15, 2024

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