Triptorelin – common side effects

Triptorelin is another medication used in gender-affirming care, particularly for transgender women (assigned male at birth) or those with androgen-dependent conditions. It is a gonadotropin-releasing hormone (GnRH) agonist, similar to leuprorelin, that suppresses the production of gonadal hormones like testosterone. While it can be effective in reducing testosterone levels and aiding in feminisation, it’s essential to be aware of potential unwanted/adverse/side effects. Here are some of them:

Side EffectDescription
Hot flashesTriptorelin can cause hot flashes or flushing, which are common side effects characterized by sudden feelings of warmth, sweating, and redness of the face and body.
Decreased libidoA decrease in libido (sex drive) can occur as a side effect of triptorelin treatment due to the suppression of testosterone levels.
Erectile dysfunctionTriptorelin may cause erectile dysfunction or difficulty achieving/maintaining erections in individuals assigned male at birth.
GynecomastiaIn individuals assigned male at birth, triptorelin can cause breast development (gynecomastia) due to the suppression of testosterone and promotion of estrogenic effects.
Mood changesSome individuals may experience mood swings, depression, or changes in emotional well-being while taking triptorelin.
FatigueFatigue or feelings of lethargy may occur as a side effect of triptorelin treatment.
HeadachesHeadaches are a common side effect of triptorelin use, though they are usually mild and temporary.
Injection site reactionsPain, redness, or swelling at the injection site are possible side effects of triptorelin injections.
OsteoporosisLong-term use of triptorelin can potentially increase the risk of osteoporosis due to decreased bone density. Bone density monitoring and supplementation with calcium and vitamin D may be recommended.
Muscle weaknessWeakness or decreased muscle strength can occur as a side effect of triptorelin treatment.
Thromboembolic eventsWhile less common, there is a risk of thromboembolic events (such as blood clots) associated with triptorelin use, particularly in individuals with other risk factors for thrombosis.
Decreased fertilityTriptorelin suppresses gonadal function, leading to decreased fertility in individuals assigned male at birth. It’s essential to discuss fertility preservation options with a healthcare provider if fertility preservation is desired.
Rare allergic reactionsAlthough rare, some individuals may experience allergic reactions to triptorelin, including rash, itching, swelling, or difficulty breathing. Immediate medical attention is necessary if any signs of an allergic reaction occur.

Updated on February 6, 2024

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