Triptorelin  in Gender-Affirming Care: An overview


Gender-affirming care encompasses a range of medical interventions aimed at aligning an individual’s physical characteristics with their gender identity. Central to this process is hormonal transition, wherein medications like triptorelin, a gonadotropin-releasing hormone (GnRH) agonist, play a vital role in suppressing endogenous hormone production and facilitating the desired hormonal changes.

Triptorelin and Hormonal Suppression

In the journey of gender transition, triptorelin serves as a key agent in suppressing endogenous hormone production. As a GnRH agonist, triptorelin works by initially stimulating the release of gonadotropins from the pituitary gland, leading to an initial surge in sex hormone levels. However, with continued use, triptorelin desensitizes the pituitary gland, resulting in the suppression of gonadotropin secretion and subsequent reduction in sex hormone production.

For transgender women (assigned male at birth), triptorelin assists in suppressing testosterone production, facilitating the feminization process by diminishing masculine secondary sexual characteristics such as body hair growth and muscle mass. Similarly, in transgender men (assigned female at birth), triptorelin aids in suppressing estrogen production, promoting masculinization by inhibiting breast development and menstrual cycling.

Facilitating Hormonal Transition

Triptorelin’s ability to effectively suppress endogenous hormone production lays the foundation for successful hormonal transition in transgender individuals. By creating a hormonal environment consistent with the individual’s gender identity, triptorelin facilitates the development of secondary sexual characteristics congruent with the desired gender, enhancing gender affirmation and overall well-being.

Dosage and Administration

Triptorelin is typically administered via subcutaneous injection, with dosages varying based on the specific treatment protocol and individual response. The frequency of administration may range from monthly to quarterly formulations, with healthcare providers specializing in transgender care tailoring the dosage and frequency to optimize hormone suppression while minimizing side effects.


Triptorelin stands as a cornerstone of hormonal transition in gender-affirming care, offering precise and effective suppression of endogenous hormone production to align with an individual’s gender identity. By facilitating the development of secondary sexual characteristics consistent with the desired gender, triptorelin plays a vital role in supporting transgender individuals on their journey towards self-affirmation, empowerment, and improved quality of life. As part of a comprehensive treatment approach, triptorelin empowers individuals to embrace their authentic selves, fostering resilience, confidence, and overall well-being in their pursuit of gender affirmation.

Updated on February 12, 2024

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