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  5. Zoladex LA Depot (goserelin)  in Gender-Affirming Care: An overview

Zoladex LA Depot (goserelin)  in Gender-Affirming Care: An overview


Zoladex LA Depot, containing Goserelin, plays a pivotal role in gender-affirming care, particularly for transgender women and non-binary individuals seeking hormone suppression. As a gonadotropin-releasing hormone (GnRH) agonist, Zoladex effectively suppresses testosterone production, contributing to the feminization process and affirming gender identity.

Hormone Suppression

Zoladex LA Depot functions by inhibiting the release of gonadotropins from the pituitary gland, thereby suppressing the production of testosterone in the testes. This leads to a significant reduction in testosterone levels, mitigating the development of secondary male characteristics and supporting the feminization of transgender women and non-binary individuals.

Regulation of Hormonal Levels

One of the key advantages of Zoladex LA Depot is its ability to provide long-term hormone suppression with a single administration. Administered via subcutaneous injection, Zoladex offers sustained release of Goserelin over several weeks, ensuring consistent hormone levels and minimizing the need for frequent dosing. This extended duration of action enhances treatment compliance and patient convenience.

Customized Treatment Plans

Healthcare providers specializing in transgender care collaborate closely with patients to develop personalized treatment plans that incorporate Zoladex LA Depot as an integral component. Dosage, injection intervals, and monitoring protocols are meticulously tailored to address the unique needs and goals of each individual, ensuring optimal efficacy and safety throughout the transition process.

Enhancing Feminization

Zoladex LA Depot contributes to the feminization process by reducing testosterone levels, allowing estrogen therapy to exert its effects more effectively. By suppressing testosterone production, Zoladex helps prevent the development of masculine traits, such as facial hair growth and deepening of the voice, while promoting the development of feminine characteristics, such as breast growth and redistribution of body fat.


Zoladex LA Depot (Goserelin) stands as a crucial component of hormone suppression in gender-affirming care, supporting the feminization process and affirming gender identity in transgender women and non-binary individuals. By providing long-term hormone suppression with minimal dosing frequency, Zoladex empowers individuals to embrace their authentic selves with confidence, resilience, and improved quality of life on their journey of gender affirmation.

Updated on February 12, 2024

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